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Natural Deep Eutectic Solvents (NADESs) combined with sustainable extraction techniques: A review of the green chemistry approach in food analysis

Cannavacciuolo, C., Pagliari, S., Frigerio, J., Giustra, C. M., Labra, M., & Campone, L.

Foods, 12.1 (2023): 56.


December 22, 2023

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Usual extraction processes for analyzing foods, supplements, and nutraceutical products involve massive amounts of organic solvents contributing to a negative impact on the environment and human health. In recent years, a new class of green solvents called natural deep eutectic solvents (NADES) have been considered a valid alternative to conventional solvents. Compared with conventional organic solvents, NADES have attracted considerable attention since they are sustainable, biodegradable, and non-toxic but also are easy to prepare, and have low production costs. Here we summarize the major aspects of NADEs such as the classification, preparation method physicochemical properties, and toxicity. Moreover, we provide an overview of novel extraction techniques using NADES as potential extractants of bioactive compounds from foods and food by-products, and application of NADEs in food analysis. This review aims to be useful for the further development of NAES and for broadening the knowledge of these new green solvents in order to increase their use for the extraction of bioactive compounds and in food analysis.

This research output is related to

Spoke 06

Tackling malnutrition

To restore resilience and defeat malnutrition

Lead organisationUniPv

Spoke leaderHellas Cena
Research projectFOODS_MALT

New food supplements ingredients for malnutrition treatment

Managed by

Principal investigators

Luca Campone,Paola Coccetti,Sandra Citterio,Paola Noverina Palestini,Massimo Labra

Referred to

Spoke 06