Funded under the National Recovery and Resilience Plan (NRRP), Mission 4 Component 2 Investment 1.3, Theme 10.
Funded under the National Recovery and Resilience Plan (NRRP), Mission 4 Component 2 Investment 1.3, Theme 10.
Highlights
Spoke 06
To achieve this goal, in connection with Spoke 4 and 5, ONFOODS WP 6.3 will lead the analysis of gut microbiome characteristics in paediatric and ageing subjects affected by malnutrition and malnutrition-related conditions, with a focus on immunological and metabolic pathways, investigation of the effects of the gut microbiome's cell wall components on the immunological and metabolic systems involved in human malnutrition, examination of the impact of diet, environmental variables, and medications on the structure and function of the human gut microbiome and the elaboration of a new algorithm supporting the prediction of gut dysbiosis associated with malnutrition and related disease.
The research team of WP 6.3 will also investigate the preventive and therapeutic effects of sustainable personalised nutritional and microbial products on malnutrition-associated gut microbiome alteration and their impact on specific malnutrition targets.
Assessing microbiome–host interaction in malnutrition (in connection with Spoke 4 and 5). a) Evaluation of gut microbiome features in paediatric and ageing subjects affected by malnutrition and malnutrition-related conditions, with a focus on immune and metabolic pathways; b) Investigation of gut microbiome cell wall constituents on immune and metabolic pathways involved in human malnutrition; c) Investigation of the diet, environmental factors and drugs influencing human gut microbiome structure and function; d) Design of an algorithm to predict the risk of gut dysbiosis associated with malnutrition and malnutrition-related diseases.
Investigation of the preventive and therapeutic action of sustainable personalised nutrition and microbial-derived products on malnutrition-associated gut microbiome alteration and effect on specific targets with malnutrition.
Enrolment of gut microbiome-based targets of intervention (M12)
Individuation of gut microbiome-based target of intervention to prevent or treat malnutrition and malnutrition-related diseases (M12).
Definition of sustainable personalised dietary intervention and gut microbiome-derived products for preventing and treating human malnutrition (M24).
