Funded under the National Recovery and Resilience Plan (NRRP), Mission 4 Component 2 Investment 1.3, Theme 10.
Funded under the National Recovery and Resilience Plan (NRRP), Mission 4 Component 2 Investment 1.3, Theme 10.
Highlights
Spoke 06
The first task of Work Package 6.1, undertaken together with Spoke 5, consists of providing a systematic evaluation of nutritional status and critical issues for target groups vulnerable to malnutrition by a) combining existing data on children affected by obesity and the elderly population at risk of malnutrition and non-communicable diseases (NCDs), b) screening for socioeconomic factors, lifestyle and diet, environmental aspects, dietary knowledge, nutritional status, body composition, functional status and disorders, quality of life, genetics, mutagenesis, phenotypic profile, endocrine disruptors exposure to (EDC), immune system function in malnourished children and geriatric populations; c) analysis of human biological samples (including samples for structural and functional analysis of the gut microbiota).
The second activity coincides with the identification and application of biomarkers of malnutrition comprising inflammatory, metabolic, microbiological, genetic, epigenetic, and biochemical pathways relevant to diseases/syndromes associated with nutrition and ageing to ensure early detection of malnutrition and quality of life restoration in target-specific categories.
WP 6.1 will lastly design an ICT database to incorporate information from various sources, including social, environmental, lifestyle, actual dietary patterns, nutritional status, biochemical, and omics data (in combination with Spokes 5 and 7). The database will be shaped around standard vocabulary concepts now used to represent clinical data.
Profiling of vulnerable targets (in connection with SPOKE 5) through: a) analyses of existing data in children affected by obesity and ageing population at risk of malnutrition and non-communicable diseases (NCDs) b) screening of socioeconomic factors, lifestyle and dietary habits, environmental factors, food knowledge, nutritional status, body composition, functional status and disability, quality of life, genetic, metagenetic, phenotypic profiles, exposure to endocrine disruptors chemicals (EDCs), immune system functions in children and aging population with malnutrition c) human-derived biological samples analysis (including samples for the gut microbiome structure analysis and function).
Identification and application of biomarkers of malnutrition (including inflammatory, metabolic, microbiological, genetic and epigenetic ones) and biochemical pathways associated with diet and age-related diseases/ syndromes for early malnutrition detection and quality of life restoration in target specific categories.
Design of an ICT database for integrating data from different sources (in connection with Spoke 5 and 7): social, environmental, lifestyle including actual dietary patterns, nutritional status,including biochemical and omics data. The database will be shaped after standard terminology concepts currently used to represent clinical information.
List of critical issues that would need consideration for reformulation of sustainable nutritional protocols target specific (M5).
Collection of biological samples (M24)
Identifying exogenous and endogenous molecules acting as biomarkers of malnutrition and related to diet in target specific categories with malnutrition (M20)
Requirement specification of the database representing all the information needed for profiling, treating and following up patients (M18)
