Funded under the National Recovery and Resilience Plan (NRRP), Mission 4 Component 2 Investment 1.3, Theme 10.
Funded under the National Recovery and Resilience Plan (NRRP), Mission 4 Component 2 Investment 1.3, Theme 10.
Contribution of nutritional and dietary factors to renal function in a...
Coordinator
Analysis of existing data on food consumption, lifestyle and biochemical/genetic parameters in Italian population groups along the lifecycle: elaboration of available datasets providing information on eating and lifestyle habits, accessibility, drivers and barriers towards a healthy diet of defined groups (children, adolescents, adults, pregnant women, older subjects) in connection with Spoke 1.
Development of an ONFOODS cohort (including relevant target groups along the lifecycle) within the geographical area covered by the participant institutions with the aim to systematically assess nutritional status, eating behaviour, physical activity and lifestyle in target populations through the application of shared procedures and questionnaire able to add information lacking from the available datasets and to provide a setting for the validation of possible biomarker (see WP 5.4.) new intervention (in connection with Spoke 4) or educational strategies (in connection with spoke 7).
Definition of the protocols for the acquisition of data and metadata relating to biomarkers of eating habits (identification of the multi-omic protocols of choice for the measurement of food biomarkers, classification of biomarkers according to specific links with diet-related risk factors, definition of criteria for the use of biomarkers for applications in interventions of diet improvement).
Investigations on selected cohorts for the validation of biomarkers in a real-life and life-long environment (biomarkers of adherence to dietary recommendations for children, biomarkers of adherence to dietary recommendations for the elderly, biomarkers of adherence to diet recommendations for pregnant women).
Report on available data and defined network (M18)
Protocols for the definition of nutritional status, eating behaviour, physical activity, and lifestyle (M12)
Report on nutritional status, eating behaviour, physical activity and lifestyle linked to quality of diet, nutrition and adherence to sustainable food patterns (M36)
Classifications of dietary patterns based on biomarkers discovery, and associations with possible diet-related health disorders (M24)
Disorder-specific dietary intervention criteria based on predictive tools based on biomarkers patterns (M36)
Fact sheets reporting the prevalence of diet-related disorders based on biomarkers among different population groups (M36)
In Italy, 45% of the adult population suffers from overweight and obesity and is, therefore, at higher risk of developing chronic diseases. Environmental factors such as unhealthy eating behavior, poor diet and a sedentary lifestyle contribute to weight gain and chronic disease risk. Diet and lifestyle can contribute to increased risk of chronic disease even in normal weight condition, through excessive increase in total and visceral fat mass, as well as high intake of harmful nutrients and non-nutrients and reduction of protective ones. Therefore, dietary-nutritional characterization is critical to understand the complex relationship between diet, nutritional status, and risk of disease. We plan to study the relationship of diet and nutritional status with kidney function, a factor that is often overlooked and whose prevalence of reduced function is thought to be underestimated.
The research will involve different activities as reported below.
