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Digested Cinnamon (Cinnamomum verum J. Presl) Bark Extract Modulates Claudin-2 Gene Expression and Protein Levels under TNFα/IL-1β Inflammatory Stimulus

Lonati, E., Sala, G., Corbetta, P., Pagliari, S., Cazzaniga, E., Botto, E., Rovellini, P., Bruni, I., Palestini, P., & Bulbarelli, A.

International Journal of Molecular Sciences, 24.11 (2023): 9201


May 24, 2024

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Epigenetic changes, host–gut microbiota interactions, and environmental factors contribute to inflammatory bowel disease (IBD) onset and progression. A healthy lifestyle may help to slow down the chronic or remitting/relapsing intestinal tract inflammation characteristic of IBD. In this scenario, the employment of a nutritional strategy to prevent the onset or supplement disease therapies included functional food consumption. Its formulation consists of the addition of a phytoextract enriched in bioactive molecules. A good candidate as an ingredient is the Cinnamon verum aqueous extract. Indeed, this extract, subjected to a process of gastrointestinal digestion simulation (INFOGEST), exhibits beneficial antioxidant and anti-inflammatory properties in an in vitro model of the inflamed intestinal barrier. Here, we deepen the study of the mechanisms related to the effect of digested cinnamon extract pre-treatment, showing a correlation between transepithelial electrical resistance (TEER) decrement and alterations in claudin-2 expression under Tumor necrosis factor-α/Interleukin-1β (TNF-α/IL-1) β cytokine administration. Our results show that pre-treatment with cinnamon extract prevents TEER loss by claudin-2 protein level regulation, influencing both gene transcription and autophagy-mediated degradation. Hence, cinnamon polyphenols and their metabolites probably work as mediators in gene regulation and receptor/pathway activation, leading to an adaptive response against renewed insults.

This research output is related to

Spoke 06

Tackling malnutrition

To restore resilience and defeat malnutrition

Lead organisationUniPv

Spoke leaderHellas Cena
Research projectFOODS_MALT

New food supplements ingredients for malnutrition treatment

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Principal investigators

Luca Campone,Paola Coccetti,Sandra Citterio,Paola Noverina Palestini,Massimo Labra

Referred to

Spoke 06